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Nurse Practitioners Salary

in Missouri

In Missouri, nurse practitioners earn $129,930 at the median, or about $62.47 an hour. The range runs from $101K at the entry level to $162K for experienced workers. Cost of living is below average (RPP 88.97), which stretches that salary to about $146,038 in buying power. Rent on a 2-bedroom averages $1,097/month, or 13.9% of estimated take-home pay.

Statewide average. Salary and cost of living vary significantly across Missouri. Jump to a metro for precise data:

$130K
Median annual
$62.47/hr
Hourly rate
$101K
Entry level (10th %)
$162K
Senior level (90th %)

So what does $130K get you in Missouri?

Estimated monthly take-home$7,845/mo
Median 2BR rent-$1,097/mo
Rent as % of take-home14% (within guideline)
Cost-of-living adjusted salary$146,038/yr
Monthly remaining after rent$6,748/mo

About nurse practitioners

Education: Master's degree
U.S. employed: 323,040
Missouri employed: 7,710
Category: Healthcare

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What this looks like in Missouri

Nurse practitioners pay in Missouri tracks closely to the national median, $130K locally vs. $132K nationwide, a 2% difference. Housing is manageable: a 2-bedroom at the HUD median costs $1,097/month, 14% of take-home, well inside the 30% guideline. Regional Price Parity sits at 88.97 (national = 100), meaning everyday costs run about 11% cheaper here. Your dollar stretches further than the headline salary suggests. Use the affordability calculator above to model your specific situation.

Compensation breakdown

Annual earnings by percentile, Missouri

Bar chart showing Nurse Practitioners salary percentiles in Missouri: 10th percentile $100,650, 25th percentile $119,910, median $129,930, 75th percentile $144,640, 90th percentile $162,060. Source: Bureau of Labor Statistics.10th$101K25th$120KMedian$130K75th$145K90th$162K
Bar chart showing Nurse Practitioners salary percentiles in Missouri: 10th percentile $100,650, 25th percentile $119,910, median $129,930, 75th percentile $144,640, 90th percentile $162,060. Source: Bureau of Labor Statistics.

Entry-level nurse practitioners (10th percentile) start around $101K. Mid-career wages sit at $130K. Top earners bring in $162K or more, a $61K spread from bottom to top.

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Nurse Practitioners salary by metro in Missouri

8 metro areas with BLS data, ranked by median pay

Metro areaMedian salaryvs. stateEmployment
St. Louis$132K+1%3,430
Kansas City$131K+1%2,730
Cape Girardeau$130K+0%200
Columbia$129K-1%330
Jefferson City$129K-1%130
St. Joseph$129K-1%140
Joplin$127K-3%230
Springfield$126K-3%660

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BLS updates this data quarterly. We'll email you when Missouri numbers change.

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Frequently asked questions

Can a nurse practitioner afford a 2BR apartment alone in Missouri?

Yes — at the median salary of $130K, rent takes 14% of take-home pay. A 2-bedroom at the HUD Fair Market Rent runs $1,097/month. That stays under the 30% guideline most financial planners use.

What’s the entry-level salary for nurse practitioners in Missouri?

The 10th-percentile wage — what new nurse practitioners typically earn — is $101K/year. Take-home on that works out to about $6,039/month. At HUD’s $1,097/month FMR, rent would take 18% of that take-home — manageable on an entry-level income.

Is nurse practitioner a high-paying job in Missouri?

Pay here is roughly in line with the national average — $130K locally vs. $132K nationally, a 2% difference.

How does Missouri compare to the national average for nurse practitioners?

Missouri pays $130K median vs. the U.S. average of $132K — that’s -2%. After adjusting for local cost of living (RPP 88.97), the purchasing-power equivalent is $146K — still ahead of the national median.

How much do nurse practitioners make in Missouri?

The median is $129,930 a year, that works out to about $62 an hour. But the range is wide: entry-level workers start around $100,650, and experienced nurse practitioners can clear $162,060. These are BLS numbers, based on employer-reported data, not self-reported surveys.

Is $130K enough to live in Missouri?

On that salary, you'd take home roughly $7,845/month after taxes. A 2-bedroom here rents for about $1,097/month, which eats 14% of your paycheck. That's under the 30% guideline most financial planners use, so the numbers work.

How far does a nurse practitioners salary go in Missouri?

Missouri has a Regional Price Parity of 88.97 (100 is the national average). That's below average, your money stretches further here than the raw salary number suggests. After cost-of-living adjustment, the median nurse practitioners salary is worth about $146,038 in national-average purchasing power.

Where do nurse practitioners get paid the most?

The table above ranks every state by median pay for this role. Keep in mind that the highest-paying states tend to have the highest costs of living, so the top salary doesn't always mean the most money in your pocket.

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